CALL FOR PAPERS Novel Therapeutics in Renal Diseases Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats
نویسندگان
چکیده
Giovanna Castoldi, Cira R. T. di Gioia, Camila Bombardi, Silvia Maestroni, Raffaella Carletti, U. Muscha Steckelings, Bjorn Dahlöf, Thomas Unger, Gianpaolo Zerbini, and Andrea Stella Clinica Nefrologica, Azienda Ospedaliera San Gerardo, Dipartimento di Scienze della Salute, Università degli Studi di Milano-Bicocca, Monza, Italy; Istituto di Anatomia Patologica, Dipartimento di Scienze Radiologiche, Oncologiche e Anatomopatologiche, Sapienza Universita’ di Roma, Rome, Italy; Unita’ Complicanze del Diabete. Istituto Scientifico San Raffaele, Milan, Italy; IMM-Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark; Department of Medicine, Sahlgrensha University Hospital/Ostra, Gothenburg. Sweden; and CARIM, Maastricht University, Maastricht, The Netherlands
منابع مشابه
Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats.
The aim of this study was to evaluate the effect of compound 21 (C21), a selective AT2 receptor agonist, on diabetic nephropathy and the potential additive effect of C21, when associated with losartan treatment, on the development of albuminuria and renal fibrosis in Zucker diabetic fatty (ZDF) rats. The experiments lasted 15 wk (from 5 to 20 wk of age) and were performed in 40 ZDF rats and 12 ...
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The hemodynamic and nonhemodynamic effects of angiotensin II on diabetic complications are considered to be primarily mediated by the angiotensin II type 1 receptor subtype. However, its biological and functional effect mediated through the angiotensin II type 2 receptor subtype is still unclear. Activation of the angiotensin II type 2 receptors has been postulated to oppose angiotensin II type...
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Diabetic nephropathy (DN) is one of the major causes of end stage renal disease. Angiotensin converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) are preferred for delaying progression of DN. This study compared the preventive renal effects of telmisartan (10 mg/kg, p.o.), an ARB that completely blocks angiotensin action, and benazepril (5 mg/kg, p.o.), an ACE inhibitor, whi...
متن کاملOveractive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy.
Diabetic nephropathy is a major cause of end-stage kidney disease, and overactivity of the endocannabinoid/cannabinoid 1 receptor (CB1R) system contributes to diabetes and its complications. Zucker diabetic fatty (ZDF) rats develop type 2 diabetic nephropathy with albuminuria, reduced glomerular filtration, activation of the renin-angiotensin system (RAS), oxidative/nitrative stress, podocyte l...
متن کاملAngiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats.
Angiotensin (ANG)-(1-7) is known to attenuate diabetic nephropathy; however, its role in the modulation of renal inflammation and oxidative stress in type 2 diabetes is poorly understood. Thus in the present study we evaluated the renal effects of a chronic ANG-(1-7) treatment in Zucker diabetic fatty rats (ZDF), an animal model of type 2 diabetes and nephropathy. Sixteen-week-old male ZDF and ...
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